منابع مشابه
Prp-c and Prp-Sc at the fetal-maternal interface.
Scrapie is a naturally occurring prion (PrP) disease causing a fatal neurodegenerative disorder in sheep and goats. Previous studies suggest that scrapie is transmitted naturally through exposure to the scrapie agent in wasted placentas of infected ewes. This study determined the distribution and biochemical properties of PrP cellular (PrP-C) and the distribution of PrP scrapie (PrP-Sc) in repr...
متن کاملPlatelet-rich plasma (PRP): what is PRP and what is not PRP?
P l atelet-rich plasma (PRP) has been a breakthrough in the stimulation and acceleration of bone and soft tissue healing. It represents a relatively new biotechnology that is part of the growing interest in tissue engineering and cellular therapy today. Because of its newness, there is a potential for misunderstanding, misuse, and application of what the practitioner may incorrectly think is PR...
متن کاملInteraction between Shadoo and PrP Affects the PrP-Folding Pathway.
UNLABELLED Prion diseases are characterized by conformational changes of a cellular prion protein (PrP(C)) into a β-sheet-enriched and aggregated conformer (PrP(Sc)). Shadoo (Sho), a member of the prion protein family, is expressed in the central nervous system (CNS) and is highly conserved among vertebrates. On the basis of histoanatomical colocalization and sequence similarities, it is suspec...
متن کاملAnti-Prion Drug mPPIg5 Inhibits PrP Conversion to PrP
Prion diseases, also known as transmissible spongiform encephalopathies, are a group of fatal neurodegenerative diseases that include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jakob disease (CJD) in humans. The ‘protein only hypothesis’ advocates that PrP, an abnormal isoform of the cellular protein PrP, is the main and possibly sole component of prion i...
متن کاملPrP knock-out and PrP transgenic mice in prion research.
Spongiform encephalopathies such as scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle or Creutzfeldt-Jacob disease (CJD) and Gerstmann-Sträussler-Scheinker syndrome (GSS) in humans is caused by a transmissible agent designated prion. The 'protein only' hypothesis proposes that the prion consists partly or entirely of a conformational isoform of the normal host protein PrP(C), d...
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ژورنال
عنوان ژورنال: Prion
سال: 2011
ISSN: 1933-6896,1933-690X
DOI: 10.4161/pri.5.2.16383